Made up largely of small businesses, the West Virginia Chamber of Commerce is a general business organization representing the interests of small and medium-sized businesses in the state. It offers various services, including advocacy and research on state policy and legislation. The website also contains a variety of resources and links for business assistance.

The West Virginia Department of Commerce is a resource developed by the West Virginia Export Council and the U.S. Commercial Service for West Virginia businesses who wish to expand into international markets through exporting. It offers export assistance, numerous links to other sources of information, and global expansion assistance. The site provides information regarding West Virginia's strategic advantages and key industries, as well as assistance on how to start a business.

The West Virginia Small Business Development Center (WVSBDC) is dedicated to helping small businesses and emerging entrepreneurs in West Virginia. It provides several free services as well as financial aid and consulting. The website offers an online resources center and a business development guide.